Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention
نویسندگان
چکیده
منابع مشابه
Stem cell pathways contribute to clinical chemoresistance in ovarian cancer.
PURPOSE Within heterogeneous tumors, subpopulations often labeled cancer stem cells (CSC) have been identified that have enhanced tumorigenicity and chemoresistance in ex vivo models. However, whether these populations are more capable of surviving chemotherapy in de novo tumors is unknown. EXPERIMENTAL DESIGN We examined 45 matched primary/recurrent tumor pairs of high-grade ovarian adenocar...
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Purpose:Withinheterogeneous tumors, subpopulations often labeled cancer stemcells (CSC) have been identified that have enhanced tumorigenicity and chemoresistance in ex vivo models. However, whether these populations are more capable of surviving chemotherapy in de novo tumors is unknown. Experimental Design: We examined 45 matched primary/recurrent tumor pairs of high-grade ovarian adenocarcin...
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Ovarian cancer is a lethal gynecological cancer causing cancer-related deaths in women worldwide. It is difficult to diagnosis at an early stage when more than 90% patients can be cured because of lack of specific symptoms and early detection markers. Most of malignant ovarian tumors are originated from the germinal epithelium of the ovary. For investigation with animal models of epithelial-der...
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Objective Articular cartilage as an avascular skeletal tissue possesses limited capacity to heal. On the other hand, it is believed that the regeneration capacity of each tissue is largely related to its stem cell contents. Little is known about the presence of mesenchymal stem cells in articular cartilage tissue. This subject is investigated in the present study. Materials and Methods Artic...
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ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2014
ISSN: 1476-4598
DOI: 10.1186/1476-4598-13-262